منابع مشابه
Aging: Dial M for Mitochondria
A major goal of aging research is to identify interventions that prolong lifespan in distantly related organisms. In recent years, genetic studies in both nematodes and rodents have reported that moderate inactivation of genes important for mitochondrial electron transport chain (ETC) function can promote longevity. We performed an RNAi screen to probe the role of ETC components in modulating l...
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The transcriptional regulatory network that controls the determination and differentiation of skeletal muscle cells in the embryo has at its core the four myogenic regulatory factors (MRFs) Myf5, MyoD, Mrf4 and MyoG. These basic helix-loop-helix transcription factors act by binding, as obligate heterodimers with the ubiquitously expressed E proteins, to the E-box sequence CANNTG. While all skel...
متن کاملDial M for Management: Next Generation NoSQL
NoSQL databases offer a powerful and flexible means of querying non-relational data. However, leading NoSQL systems typically achieve high performance goals while minimizing support for traditional data management services and defying the establishment of solid formal models. In particular, the systems generally shun tools and design principles rendered conventional by the long history of RDBMS...
متن کاملMitochondria, obesity and aging
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متن کاملMitochondria, Oxidants, and Aging
The free radical theory of aging postulates that the production of intracellular reactive oxygen species is the major determinant of life span. Numerous cell culture, invertebrate, and mammalian models exist that lend support to this half-century-old hypothesis. Here we review the evidence that both supports and conflicts with the free radical theory and examine the growing link between mitocho...
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ژورنال
عنوان ژورنال: Aging
سال: 2010
ISSN: 1945-4589
DOI: 10.18632/aging.100118